Age-Related Decline May Be Linked to High Blood Sugar Levels

< Dec. 31, 2008 > -- Rising blood glucose levels have been identified by scientists as a possible contributing factor in age-related cognitive decline.  

A recent study found in the Annals of Neurology established that rising blood sugar levels, a normal part of aging, affect a part of the brain called the hippocampus. This area of the brain is critical to learning, memory, and other cognitive functions.  

Blood Sugar Regulation  

Senior study author Dr. Scott Small, an associate professor of neurology at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain at Columbia University Medical Center in New York City states, "This would suggest that anything to improve regulation of blood glucose would potentially be a way to ameliorate age-related memory decline,"

The findings may also help explain why people who exercise do not have as many cognitive problems as they age. The clinical implication being exercise helps to stabilize blood glucose levels and helps maintain cognitive function.

Exercise and Its Impact on Blood Glucose 

Rising blood sugar levels are a suspected mechanism, but this could be good news as this factor may be easily amenable to change. As such, physical exercise might just be an uncomplicated, yet effective antidote.

"We had previously shown that physical exercise strengthens a part of the brain involved with aging but, at the time, we didn't know why physical exercise would have this selective benefit," Dr. Small says. "Now we have a proposed mechanism. We think it's because subjects who exercised had better glucose handling."

New Insight On Specific Brain Region  

It is well known that damage to the hippocampus is evident with Alzheimer's disease, and there has been some suggestion that this region of the brain is also affected by normal aging. The researchers used MRI to record the functioning of the hippocampus in 240 healthy older people with an average age close to 80. Sixty of the participants had type 2 diabetes, while 74 had brain "infarcts" - some damage to brain tissue.

The studies indicated that diabetes and infarcts were each linked with separate areas of the hippocampus, indicating that different mechanisms are at work in each disorder.
These findings were were subsequently confirmed in animal tests 

"The paper identifies an etiology [cause] for normal age-related memory decline," Small explains. "Elevations in blood glucose levels differentially target the dentate gyrus part of the hippocampus implicated in aging and, as we age, we develop a slight but gradually worsening difficulty in handling blood sugar levels."

That difficulty coincides with the beginning of loss of cognitive function, Dr. Small concludes.

Further Research Expected

At this time, expert opinion has not reached a final consensus. Some experts such as Dr. Bryan Freilich, a clinical neuropsychologist at Montefiore Medical Center in New York City encourages continued research. He says, "In my opinion, that's an interesting hypothesis and needs to be studied - that exercise helps improve cognitive functioning through that mechanism, but I think there are other mechanisms as well,"

This early study may provide useful clinical information. Dr. Mark Mapstone, an associate professor of neurology at the University of Rochester Medical Center in New York, said: "If these findings are replicated and confirmed, I think the implications could be very important, specifically, that maintaining optimal blood sugar levels throughout aging is a feasible way to [slow or prevent] cognitive decline. It goes beyond diabetes to look at people who don't have diabetes. The implication is even if you don't have a clinical condition of diabetes, that you can still do something about cognitive aging."

Always consult your physician for more information.

What Is Blood Glucose Monitoring?

Blood glucose levels, also called blood sugar levels, are signs of how well diabetes is being controlled and how well the plan of care is working. Checking blood glucose levels regularly is very important in proper diabetes management. Current methods of blood sugar monitoring require a blood sample. Blood sugar monitoring can be done at home with a variety of devices to obtain the blood sample.

Persons with diabetes may have to check their blood sugar levels up to four times a day. Blood sugar levels can be affected by several factors, including diet, diabetes medication, exercise, and illness.  

The usual method involves obtaining a drop of blood by pricking the finger. A finger prick can be done with a a special needle called a lancet or with a spring-loaded lancet device that punctures the fingertip quickly. The drop of blood is placed on a  test strip that is then placed in a blood glucose monitor which reads the blood sugar level.

There are many types of monitors on the market today, ranging in price, ease of use, size, portability, and length of testing time. Each monitor requires its own type of testing strip. Blood glucose monitors have been found to be accurate and reliable if correctly used, and most monitors provide results within two minutes. Some glucose monitors can also give verbal testing instructions and verbal test results for people who are visually or physically impaired. There are also glucose monitors available that provide verbal instructions in Spanish and other languages.

Maintaining a healthy blood sugar level is important in the management of diabetes. Blood sugar levels over 200 mg/dL (mg/dL = milligrams of glucose per deciliter of blood) or under 60 mg/dL are considered unhealthy.

High blood sugar levels (above 200 mg/dL) may be a sign of inadequate levels of insulin, caused by diabetes medication, overeating, lack of exercise, or other factors.

Low blood sugar levels (below 60 mg/dL) may be a caused by taking too much insulin, skipping or postponing a meal, over-exercising, excessive alcohol consumption, or other factors.

Persons with diabetes must stay alert for symptoms that can lead to clinical complications. Making good health choices such as getting regular check-ups, carefully self-monitoring blood sugar, controlling your weight, eating healthy, and getting regular exercise can keep you on the right track. 

Always consult your physician for more information.